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Recommended Reading ListFebruary 2005Access Instructions: To access the full-text articles listed in this month's Recommended Reading List, click here to log on to the EFORT portal. Go to the section called File Cabinet, accessible through the navigation menu on your portal homepage. Here you will find a folder with the full-text articles that make up this month's shortlist. This month's 'must-read' articles by category Radiographic Progression of Knee OA "Thrust during ambulation and the progression of knee osteoarthritis." Chang A, et al. Arthritis & Rheumatism 2004; 50:3897-3903. "The effect of body weight on progression of knee osteoarthritis is dependent on alignment." Felson DT, et al. Arthritis & Rheumatism 2004; 50:3904-3909. The first paper showed that varus thrust is associated with increased odds of radiographic progression in medial compartment knee OA even after adjustment for varus malalignment and body mass index at baseline. This effect is presumably mediated by increases in dynamic adduction moment during gait. The second paper showed that there was effect modification between baseline malalignment and body mass index in predicting radiographic progression in knee OA. There was an association between increasing body mass index and radiographic progression; however, when malalignment was considered, the association remained significant only in those knees with moderate malalignment at baseline. The authors suggest that weight loss to reduce progression may not be effective in those with severely malaligned knees. Prof Marc Hochberg, MD, MPH, University of Maryland, USA. Improving Outcome in Fracture Healing "Perspective: Parathyroid hormone - a drug for orthopedic surgery?" Skripitz R, Aspenberg P. Acta Orthop Scand 2004;75 (6):654-662. Based on a review of clinical and preclinical studies the authors suggest that there are good reasons to believe that PTH treatment may stimulate fracture healing and improve implant fixation in man. Prof Anders Rydholms, Professor of Orthopaedic Surgery, Lund University, Sweden Vertebral Fractures "Association of Severe Vertebral Fractures with Reduced Quality of Life. Reduction in the incidence of severe vertebral fractures by teriparatide." Crans GG, Silverman SL, Genant HK, et al. Arthritis & Rheumatism 2004; 50: 4028-4034. Parathyroid hormone, in carefully regulated doses, can significantly reduce the risk of new or worsening of vertebral fractures. Edward D. Harris, Jr., MD, George DeForest Barnett Professor of Medicine Emeritus at Stanford University in California, USA. Adjunctive Therapy in Knee OA "Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee." Berman BM, Lao L, Langenberg P., et al. Annals of Internal Medicine 2004;141: 901-910. viewable at: www.annals.org/cgi/content/full/141/12/901 This paper provides, in a placebo-controlled study, evidence that acupuncture seems to provide improvement in both function and pain relief as an adjunctive therapy for osteoarthritis of the knee. Edward D. Harris, Jr., MD, George DeForest Barnett Professor of Medicine Emeritus at Stanford University in California, USA. Anti-Sm and Anti-RNP Antibody Tests "Guidelines for Immunologic Laboratory Testing in the Rheumatic Diseases: anti-Sm and anti-RNP antibody tests." E Benito-Garcia, PH Schur, R Lahita et al. Arthritis Care and Research 51: 1030-1044. This article provides an evidence base for the role of the use of anti-Sm and anti-RNP antibody tests in lupus patients and other rheumatic conditions. The discussion includes their sensitivity and specificity for diagnosis and their use for prognosis determination e.g. nephritis and central nervous system involvement. Dr Bridget Griffiths, Consultant Rheumatologist, Freeman Hospital, Newcastle upon Tyne, UK. Specialty: SLE. Prostheses Registry "Documentation of hip prostheses used in Norway. A critical review of the literature from 1996 - 2000." Aamodt A, Nordsletten L, Havelin L I, Indrekvarn K, Utvåg S E, Hviding K. Acta Orthop Scand 2004; 75(6); 663-676. The authors performed a systematic review of the scientific documentation of hip prostheses used in Norway. They found that most studies were observational and only one-tenth were randomized studies. For one-third of the implants no scientific documentation could be found. This is an ackward situation; the authors emphasize that new implants should be introduced through preclinical testing, radiostereometric analysis, and randomized trials. Prof Anders Rydholms, Professor of Orthopaedic Surgery, Lund University, Sweden Note: Acta Orthopaedica Scandinavica is now fully Open Access, and full text articles are immediately available at www.tandf.co.uk/journals/titles/00016470.asp Open Access Identification of Arthritis Genes "Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation" Adarichev VA, Vermes C, Hanyecz A, Mikecz K, Bremer EG, Glant TT. Arthritis Research & Therapy 2005, 7:R196-R207. viewable at: http://arthritis-research.com/content/7/2/R196 Investigation of the entire mouse genome by DNA mircoarray technology has led to identification of 37 arthritis 'signature' genes, which are expressed prior to the onset of clinical symptoms. Reading List Access Instructions: To access the full-text articles listed in this month's Recommended Reading List, click here to log on to the EFORT portal. Go to the section called File Cabinet, accessible through the navigation menu on your portal homepage. Here you will find a folder with the full-text articles that make up this month's shortlist. | |
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